Everyone who has bronchial asthma (BA) knows that a choking attack can be blocked by the drugs dilating bronchi. Many people with BA, who use these drugs, don’t think about how they act and what’s the difference between them. However, knowing it is very important for their proper use. Adrenaline is the most potent bronchodilator. In the human body, they are produced by adrenal glands. Until the mid-twentieth century, adrenaline injections were often used for the treatment of an asthma attack. Every patient who has used these drugs knows that this can lead to a strong heartbeat, agitation, and sometimes high blood pressure.
|Drug Name||Doses||Per Pill||Visit Pharmacy|
|Generic Ventolin||100 mcg||$24.53|
|Generic Ventolin||4 mg, 2 mg||$0.50|
This happens because they affect the adrenoceptors of both the bronchi and the heart. The receptors can be compared to the buttons. If you press one button, the bronchi will dilate, and if you click on the other — your heart will beat faster (the first buttons are called β2-receptors, and the second — β1-receptors). Adrenaline affects both types of receptors at once. Therefore, along with breathing relief, an increased heartbeat appears. For many people, especially those with heart problems, this is unacceptable. Therefore, other substances were created, which mainly affect β2-receptors — selective β2- adrenomimetics.
Ventolin mode of application
The optimal method of administering anti-asthma drugs is inhalation, as in this case, the medication is delivered directly to the place, where it must act — to the airways. Benefits of the Ventolin inhalation method of administration are the fast onset of action of the drug, significantly lower therapeutic dose, and reduced risk of developing side effects.The amount of Ventolin entering the bronchi depends on the delivery system, that is, the inhaler selected. There are several types of delivery systems: nebulizers, powder inhalers, metered-dose aerosol inhalers, and metered-dose inhalers with spacers.
Nebulizers have the longest history of use — they have been used for almost 150 years. The word “nebulizer” is derived from the Latin “nebula” (“fog” or “cloud”) was first used in 1874 to indicate the device, converting a liquid substance into an aerosol for medical purposes. For use with a nebulizer, the company “GlaxoSmithKline” has developed this form of salbutamol as Ventolin. Benefits of Ventolin nebulizer are:
- easy inhalation technique,
- no need for forced inhale,
- possibility of delivery of the high dose of the drug and use of the system in the older people and children under one-year-old (even in the most severe conditions).
Dose aerosol inhalers are some of the most famous and widespread drug-aerosol delivery systems
Ventolin contains a suspension preparation and a carrier gas (freon or other) under pressure. The benefits of the drug are its convenience, portability, speed of the procedure, and affordable price. Benefits of Ventolin include high speed of aerosol (this leads to the fact that about 80% of the drug settles on the back of the pharynx, 10% remains in the inhaler, and only 10% gets into the lungs). Besides, upon contact of freon with a soft palate, a reflex interruption of inhaling may occur (“cold freon effect”), which also reduces the amount of the drug entering the lungs.
For some patients, a common shortcoming of aerosol inhalers is the difficulty of coordinating inhale with the release of the drug from the inhaler. As a result, some patients are inhaled incorrectly. Spacers were invented to solve the problems of the coordination of patients inhale and drug release. Ventolin is a non-freon aerosol inhaler, using hydrofluoroalkane propellant as a carrier. If necessary, you can use the spacer with this inhaler. The common dosage depends on the patient’s age and severity of the attack and is 1–2 doses of the drug. If you know that you will have a physical activity causing shortness of breath, or contact with an allergen (for example, a trip to the country), you should make one or two inhalations of the drug before this to prevent an asthma attack.