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AAPS 2014: Foreign Particulate and Glass Delamination Investigations using Automated Raman/LIBS

Authors & ContributorsRebekah ByrneDavid ExlineEmily Landsperger

November 19, 2014

Foreign particulate matter in drug products is a common problem in the pharmaceutical industry that can have major impacts on pharmaceutical companies, from both financial and safety aspects. While manual particulate characterization is best suited for many investigations, automated Raman /LIBS analysis can offer additional insight and investigative solutions to contamination issues, including foreign particulate matter and glass delamination. The purpose of this poster presentation is to describe the methodologies and effectiveness of utilizing automated Raman / LIBS analysis techniques versus routine manual testing methodologies. When launching an investigation, it is important to determine the scope of the project, so that one can best determine which method will provide the most informative results.

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