Investigation of the Microstructure of Combination Dry Powder Inhaler Formulations by Atomic Force Microscopy and Raman Chemical Imaging

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Presented at: Respiratory Drug Delivery 2012
Authors: Chris Vernall1, Oksana Olkhovyk2, Ryan J. Priore2, Robert Price1 and Jagdeep Shur1

  1. Pharmaceutical Surface Science Research Group, Department of Pharmacy and Pharmacology, University of Bath, Bath, BA2 7AY, UK
  2. Gateway Analytical, Pittsburgh, USA

Release Date: May 17, 2012

Introduction:
The microstructure of combination DPI formulations is complex and is related to the surface interfacial interactions between components of the formulation, which define the structure and thereby performance of the formulation (1, 2, 3). Previous studies have attempted to investigate the microstructure of combination DPI formulations using a combination of atomic force microscopy (AFM) and Raman chemical imaging (RCI) (4). These studies, however, have focused primarily on the surface interaction between two different drugs and their aerodynamic particle size distribution.

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