Gateway Analytical to Present Advancements in Particle Sizing Research at Pittcon 2011

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PITTSBURGH, March 7, 2011 — Particle size advancements in nasal spray suspensions using Raman chemical imaging will be presented by scientists at Gateway Analytical, March 15-16 at the Pittcon Conference and Expo 2011, the world’s largest annual conference and exposition for laboratory science, at the Georgia World Congress Center in Atlanta.

Presentation highlights include:

Surface Wetting of Sample Substrates for Ingredient-Specific Particle Sizing
March 15; Red Area on Exposition Floor — Hall B, Aisle 400
Presented by: Ryan J. Priore, Ph.D., Director of Applications & Contract Services at Gateway Analytical

Accurate knowledge of the active pharmaceutical ingredient particle size is critical for determining the ultimate dissolution rate in the mucous membrane of the nasal cavity. When preparing dried samples of nasal suspensions for ingredient-specific particle sizing (ISPS) utilizing Raman chemical imaging (RCI), the source of particle aggregation or agglomeration is ambiguous. Particles may exist as true agglomerates, or particles may agglomerate during the drying process.

This study demonstrates the advantages of sample substrate pretreatment for the minimization of particles agglomeration during the sample preparation process. RCI for a nasal spray suspension, along with a polystyrene microsphere sizing standard, will be presented.

Sizing Standard Development for Raman Chemical Imaging
March 16, 10:35 a.m.; room 407
Presented by: Ryan J. Priore, Ph.D., Director of Applications & Contract Services at Gateway Analytical

This talk will summarize the progress made in utilizing NIST traceable polystyrene microspheres as a particle sizing calibration standard for wide-field RCI of micron sized Orally Inhaled and Nasal Drug Product particles. Wide-field RCI particle size distributions will be discussed for various morphological parameters. A representative nasal spray sample will be reviewed to demonstrate the application of this methodology.

For more information on these presentations, visit

About Gateway Analytical
Based in Gibsonia, Pa., Gateway Analytical, LLC partners with companies in need of high-quality laboratory analysis that do not have the time, resources or capabilities for specialized, comprehensive testing. Through conventional and innovative testing methods, the company provides expert laboratory services and analytical solutions for the pharmaceutical, forensic and materials science industries. Gateway Analytical is a subsidiary of ChemImage Corporation, a leader in chemical imaging technology and instrumentation.

Media Contact:
Linda Batykefer
Marketing Manager
Tel: +1 412-241-7335, ext. 269


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