Identification of Drug Forms in Solid Solutions Using Wide-field Raman Chemical Imaging

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Drug Forms in Soild Solutions

Fast dissolving polymers such as polyvinyl-pyrrolidone (PVP) are efficient delivery vehicles of poorly water-soluble and poorly permeable drugs. PVP is hydrophilic and compatible with a wide array of polymers and copolymers; therefore it is used extensively in the pharmaceutical industry to increase the dissolution of commonly used drugs.

Problems in achieving expected rate of drug dissolution may be attributed to a high content of drug in the solid solution due to:

  • Molecular dispersion of the drug in the carrier
  • Precipitation of a metastable polymorph of the drug with a solubility higher than that of a stable form

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David Exline has more than 20 years of experience in managing and administering analytical laboratory and consulting services. As President of Gateway Analytical, he oversees the company’s day-to-day operations, business growth and service areas.