Featured Applications

Below you will find a collection of featured application examples that discuss in detail the different types of techniques Gateway Analytical uses for analyzing these types of applications.

Multilayered Transdermal Patch

Evaluating API Heterogeneity in a Multilayered Transdermal Patch

Transdermal patches are a popular choice for drug delivery because of the sustained drug levels, low side effects, reduced hepatitic first-pass effect and ease of application, including self–administration. The basic components of any transdermal delivery system include the drug(s) dissolved or dispersed in a reservoir or inert polymer matrix; an outer backing film of paper, […]

Investigation of Polymorphic Transformations Using Raman Chemical Imaging & Differential Scanning Calorimetry

Investigation of Polymorphic Transformations Using Raman Chemical Imaging & Differential Scanning Calorimetry

Polymorphs are chemicals of identical molecular structure with different crystal lattice formations. Screening for polymorphs is crucial for drug research and development since the crystal form of the active pharmaceutical ingredient (API) directly correlates with its pharmacokinetic properties. Additional property differences among polymorphs include: solubility, stability, dissolution rate, miscibility and excipient compatibility in the final […]

Identification of Drug Forms in Solid Solutions Using Wide-field Raman Chemical Imaging

Identification of Drug Forms in Solid Solutions Using Wide-field Raman Chemical Imaging

Fast dissolving polymers such as polyvinyl-pyrrolidone (PVP) are efficient delivery vehicles of poorly water-soluble and poorly permeable drugs. PVP is hydrophilic and compatible with a wide array of polymers and copolymers; therefore it is used extensively in the pharmaceutical industry to increase the dissolution of commonly used drugs. Problems in achieving expected rate of drug […]

Characterization of a Controlled Release Bead Using Wide-Field Raman Chemical Imaging

Characterization of a Controlled Release Bead Using Wide-Field Raman Chemical Imaging

A controlled release device is a complex system, designed to release the drug product’s active pharmaceutical ingredient (API) gradually and predictably over a specified period of time. Controlled release systems offer several advantages over traditional drug delivery including tailoring of drug release rates and site-specific delivery. A typical manufacturing strategy for controlling release profile is […]