Investigating the Miscibility of an API in Soluplus Dispersions by Raman Chemical Imaging Technique

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Presented at: 2012 AAPS Annual Meeting and Exposition
Authors: Oksana Olkhovyk1, Nigel Langley2, Shaukat Ali2, 1. Gateway Analytical, 2. BASF
Release Date: October 16, 2012

This poster session discusses the miscibility of drugs in the solid dispersions as it has been subject of continued interest in the development of oral dosage. The study was aimed at investigating the miscibility of carbamazepine in Soluplus matrix by using a Raman Chemical Imaging (RCI) technique.

Introduction:
Raman Chemical Imaging (RCI) spectroscopy was used to investigate the solubility of model drug Carbamazepine in solid dispersions in Soluplus, a graft polymer comprised of polyethylene glycol, polyvinylacetate and polyvinylcaprolactame. Soluplus has been used to increase the solubility and bioavailability of poorly soluble molecules.

RCI is considered one of the most powerful analytical tools for study of molecular composition, structure, identification of polymorphs and pseudo-polymorphs and other solid-state characteristics of solid solutions as it provides insight on the structure changes for each insoluble or precipitated components. Wide-field Raman Chemical Imaging (RCI) approaches image construction by assembling spatially-resolved frames into a Raman hypercube with spatial and wavelength information for each frame. Contrast at a desired wavelength of the image hypercube reveals the presence and absence of Raman scattering, and therefore, identifies the species of interest at each pixel.

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Dr. Oksana Olkhovyk Ph.D., plays an important role supporting analytical testing services as the Senior Scientist at Gateway Analytical. She has over 15 years experience in Raman spectroscopy, imaging and material characterization. Dr. Olkhovyk has worked to support hundreds of projects as a scientific liaison between Gateway Analytical and their customers, as well as academic and industrial collaborators.

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