White Papers
White Paper: Using Raman Chemical Imaging to Analyze Inhaled Combination Therapies
White Paper Preview: Since the approval of the Seretide (Advair) fluticasone/salmeterol dry powder inhaler in 1999, inhaled therapies that combine a bronchodilator, often a longacting beta agonist (LABA), with a maintenance drug, usually an inhaled corticosteroid (ICS), have taken over a large portion of the asthma and COPD markets. And, increasingly, a long-acting muscarinic antagonist [...]
White Paper: Analysis of Multi-Component Engineered Particles for Inhalation by Raman Chemical Imaging
White Paper Preview: One of the most promising trends in inhaled therapies over the past few years is the creation of particles that contain multiple active ingredients. Some studies have suggested that two, or even three, APIs deposited in the same location in the lung may have a synergistic effect. Combination of the active ingredients [...]
White Paper: Analysis of Aggregates in Nasal Spray Suspensions
A recently introduced technique that uses Raman Chemical Imaging RCI) for ingredient-specific particle sizing (ISPS) provides a greatly improved method of analyzing aggregates and agglomerates in nasal spray suspension formulations.
White Paper: Forensics Can Help Identify Particulate Contamination
New forensic techniques and approaches are essential for resolving potential safety issues. White Paper Preview: Manufacturers of parenteral products must accept and deal with increasingly strict regulatory expectations for product purity. Quickly and completely identifying a contaminant and its source have become key considerations in dealing with potential product safety and regulatory compliance issues. Failing [...]
White Paper: An Introduction to Pharmaceutical Forensics
Pharmaceutical forensics is a specialized field of examination that applies forensic expertise, analysis and problem solving principles to pharmaceutical deviation investigations. Often times, particulate contamination occurs in products, processes and customer-related investigations. In other instances, the need for detailed problem solving methodologies are required to determine the source of stains, discolorations, product defects and to [...]
